Structure of PDB 6gom Chain D

Receptor sequence
>6gomD (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYEDSYRKQVVIDGETC
LLDILDTAGAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDS
EDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAF
YTLVREIRKHK
3D structure
PDB6gom Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
ChainD
Resolution1.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP D G13 G15 K16 S17 A18 V29 D30 Y32 G60 N116 K117 D119 L120 S145 A146 G16 G18 K19 S20 A21 V32 D33 Y35 G59 N110 K111 D113 L114 S139 A140
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gom, PDBe:6gom, PDBj:6gom
PDBsum6gom
PubMed30683716
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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