Structure of PDB 6fym Chain D

Receptor sequence
>6fymD (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQA
KKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKG
TYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKN
PQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB6fym A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity.
ChainD
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EBB D H1682 G1683 T1684 D1685 Y1701 G1703 Y1714 Y1721 S1722 Y1727 H70 G71 T72 D73 Y89 G91 Y102 Y109 S110 Y115
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

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Molecular Function
External links
PDB RCSB:6fym, PDBe:6fym, PDBj:6fym
PDBsum6fym
PubMed30344052
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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