Structure of PDB 6fvj Chain D

Receptor sequence
>6fvjD (length=223) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
AKQAAPTLYIFPHAGGTAKDYVAFSREFSADVKRIAVQYPGGLPPLESIP
TLADEIFAMMKPSARIDDPVAFFGHSMGGMLAFEVALRYQSAGHRVLAFF
VSACSAPGHIRYKQLQDLSDREMLDLFTRMDDEFFVGALPTLRAVRAIAG
YSCPPETKLSCPIYAFIGDKDWIATQDDMDPWRDRTTEEFSIRVFPGDHF
YLNDNLPELVSDIEDKTLQWHDR
3D structure
PDB6fvj Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in Mycobacterium tuberculosis.
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.6: acetylesterase.
3.1.2.-
3.1.2.2: palmitoyl-CoA hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D R49 F51 R26 F28
BS02 E9H D H36 A37 S104 M105 I185 H236 H13 A14 S76 M77 I148 H199
Gene Ontology
Molecular Function
GO:0008126 acetylesterase activity
GO:0016787 hydrolase activity
GO:0047617 fatty acyl-CoA hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0052167 symbiont-mediated perturbation of host innate immune response
GO:0071770 DIM/DIP cell wall layer assembly
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fvj, PDBe:6fvj, PDBj:6fvj
PDBsum6fvj
PubMed30292819
UniProtP9WQD5|TESA_MYCTU Thioesterase TesA (Gene Name=tesA)

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