Structure of PDB 6fqs Chain D

Receptor sequence
>6fqsD (length=189) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVY
3D structure
PDB6fqs A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
ChainD
Resolution3.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D K460 L462 N463 K466 H515 V626 R629 K44 L46 N47 K50 H99 V176 R179
BS02 dna D D437 K460 D21 K44
BS03 MN D D508 D510 D92 D94
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6fqs, PDBe:6fqs, PDBj:6fqs
PDBsum6fqs
PubMed29538767
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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