Structure of PDB 6fqq Chain D

Receptor sequence
>6fqqD (length=63) Species: 9606 (Homo sapiens) [Search protein sequence]
AAGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFI
NARRRLLPDMLRK
3D structure
PDB6fqq TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
ChainD
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D N170 L171 N217 R221 N4 L5 N51 R55 PDBbind-CN: Kd=388.6nM
BS02 dna D Y191 K197 I216 R219 R220 Y25 K31 I50 R53 R54 PDBbind-CN: Kd=388.6nM
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6fqq, PDBe:6fqq, PDBj:6fqq
PDBsum6fqq
PubMed30060237
UniProtQ15583|TGIF1_HUMAN Homeobox protein TGIF1 (Gene Name=TGIF1)

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