Structure of PDB 6foq Chain D

Receptor sequence

>6foqD (length=458) Species: 115828 (Streptomyces maritimus)

QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTST
PDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSR
RLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLS
RKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAF
EFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAP
PLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLP
YRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQL
ELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREG
YRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFR
LNQNIPPS

3D structure

• PDB: 6foq Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.
• Chain: D
• Resolution: 1.386 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H78 S137 T245
• Catalytic site (residue number reindexed from 1): H74 S133 T241

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	D	W37 V73 R74 G75 G76 G77 H78 S79 S84 L94 G134 V135 V136 G140 G142 G143 L144 L146 F150 V200 V201 Y416 N418 L455 N456	W33 V69 R70 G71 G72 G73 H74 S75 S80 L90 G130 V131 V132 G136 G138 G139 L140 L142 F146 V196 V197 Y412 N414 L451 N452
BS02	OXY	D	L117 G134 V136 T139	L113 G130 V132 T135
BS03	OXY	D	W37 H138	W33 H134

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0042802 identical protein binding
• GO:0050660 flavin adenine dinucleotide binding
• GO:0071949 FAD binding

External links

• PDB: RCSB:6foq, PDBe:6foq, PDBj:6foq
• PDBsum: 6foq
• PubMed: 29686059
• UniProt: Q9KHK2