Structure of PDB 6f5p Chain D

Receptor sequence

>6f5pD (length=708) Species: 100673 (Influenza C virus (C/Johannesburg/1/66))

MSKTFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCD
EYLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEK
QFVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQK
LRIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLELRDESVP
LPFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIR
LPKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRP
KDKPLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGIGRASKKI
PEISLTQDVITTEGLKQSENKLPEPRSFPRWFNAEWMWAIKDSDLTGWVP
MAEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECR
LFPGKIKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHLNKDDG
MYTIITFEFSIREPNLEKHQKYTVFEAGHTTVRMKKGESVIGREVPLYLY
CRTTALSKIKNDWLSKARRCFITTMDTVETICLRESAKAEENLVEKTLNE
KQMWIGKKNGELIAQPLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKIL
MALEGDKKNKSSFGFNPEGLLEKIEECLINNPMCLFMAQRLNELVIEASK
RGAKFFKT

3D structure

• PDB: 6f5p A Mechanism for the Activation of the Influenza Virus Transcriptase.
• Chain: D
• Resolution: 4.14 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	D	D93 E104	D93 E104

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6f5p, PDBe:6f5p, PDBj:6f5p
• PDBsum: 6f5p
• PubMed: 29910112
• UniProt: Q9IMP5|PA_INCJH Polymerase acidic protein (Gene Name=PA)