Structure of PDB 6evj Chain D

Receptor sequence

>6evjD (length=708) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

SMENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYS
DFHFIDLEGNTIVKENNAMLKHRFEIIEGQERNIAWTIVNSICNMTENSK
PRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSFDG
EEMATDDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSEKLEEEFS
YPPTFQRLANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQ
IESFDPRTIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKD
AKACLDTFWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLK
KTNHLKWGLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEF
NKASELTNSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMK
AVYINTALLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHL
RNDTDVVNFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPV
YLYVRTNGTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPF
FRNRENDWPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAE
SRKLLLLIQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFL
KAVQLSMG

3D structure

• PDB: 6evj Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
• Chain: D
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	M472 H505 L506 R507	M466 H499 L500 R501
BS02	rna	D	H326 K328 W363 G366 G368 Q369 A370 P371 K373 Y388 P393 R503 H505 V512 N514 K534 R561 T562 N563 G564 K569	H320 K322 W357 G360 G362 Q363 A364 P365 K367 Y382 P387 R497 H499 V506 N508 K528 R555 T556 N557 G558 K563

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting

External links

• PDB: RCSB:6evj, PDBe:6evj, PDBj:6evj
• PDBsum: 6evj
• PubMed: 29202182
• UniProt: H6QM92