Structure of PDB 6erf Chain D

Receptor sequence
>6erfD (length=520) Species: 9606 (Homo sapiens) [Search protein sequence]
NKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIA
LVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQA
DFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLK
KCDISLQFFLPFSLPFRLGGHGKGITEQQKEGLEIVKMVMISLEGEDGLD
EIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERV
KKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVP
FSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEA
AAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYV
QLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDT
LEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEV
TTKSQIPLSKIKTLFPLIEA
3D structure
PDB6erf XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
ChainD
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D R271 T275 R431 R249 T253 R409
BS02 dna D I245 K265 Y397 A401 N402 I223 K243 Y375 A379 N380
BS03 peptide D L68 Q73 Y74 D106 D109 I112 M115 Q119 S143 K144 S145 Q146 I149 L63 Q68 Y69 D101 D104 I107 M110 Q114 S138 K139 S140 Q141 I144
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6erf, PDBe:6erf, PDBj:6erf
PDBsum6erf
PubMed30291363
UniProtP13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)

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