Structure of PDB 6egd Chain D

Receptor sequence
>6egdD (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
GSRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVA
VKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMP
NGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSAN
ILLDEAFTAKISDFGLARATAYMAPEALRGEITPKSDIYSFGVVLLEIIT
GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSV
ASQCLHEKKNKRPDIKKVQQLLQEMT
3D structure
PDB6egd Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
ChainD
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N311 K313 A315 N316 D329
Catalytic site (residue number reindexed from 1) N145 K147 A149 N150 D163
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J87 D M192 A211 K213 Y262 Y264 M265 G268 L318 S328 D329 M31 A50 K52 Y96 Y98 M99 G102 L152 S162 D163
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6egd, PDBe:6egd, PDBj:6egd
PDBsum6egd
PubMed30679311
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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