Structure of PDB 6ea9 Chain D

Receptor sequence
>6ea9D (length=195) Species: 10254 (Vaccinia virus WR) [Search protein sequence]
SMAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDK
YMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNY
YALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMN
ALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP
3D structure
PDB6ea9 Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
ChainD
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9BG D H17 A18 F19 R60 I105 H18 A19 F20 R61 I106
BS02 9BG D A129 V130 Y138 K142 A145 R182 R184 K186 A130 V131 Y139 K143 A146 R183 R185 K187
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0061507 2',3'-cyclic GMP-AMP binding
Biological Process
GO:0052170 symbiont-mediated suppression of host innate immune response
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ea9, PDBe:6ea9, PDBj:6ea9
PDBsum6ea9
PubMed30728498
UniProtQ01225|POXIN_VACCW Poxin (Gene Name=OPG188)

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