Structure of PDB 6e42 Chain D

Receptor sequence

>6e42D (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]

VGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHL
TDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSAALEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLV
EIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDH
VNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVF
QCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFV
LSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPSKLEAKGT
GGTDLMNFLKTVRSTTEKSLLK

3D structure

PDB

6e42 High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.

Chain

Resolution

2.103 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.13.11.52: indoleamine 2,3-dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HQJ	D	A116 E119	A96 E99
BS02	HEM	D	F163 V170 F214 F226 S263 A264 F270 F291 R343 H346 I349 V350 Y353 I354 L384 F387 L388 V391	F143 V150 F194 F206 S243 A244 F250 F271 R323 H326 I329 V330 Y333 I334 L355 F358 L359 V362
BS03	HQJ	D	Y126 V130 F163 F164 S167 G262 S263 A264	Y106 V110 F143 F144 S147 G242 S243 A244
BS04	HQJ	D	F270 L339 L342 R343 H346	F250 L319 L322 R323 H326
BS05	HQJ	D	A116 L120 P121 W253	A96 L100 P101 W233

Gene Ontology

	Molecular Function
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0009055	electron transfer activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0020037	heme binding
GO:0033754	indoleamine 2,3-dioxygenase activity
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

	Biological Process
GO:0002376	immune system process
GO:0002666	positive regulation of T cell tolerance induction
GO:0002678	positive regulation of chronic inflammatory response
GO:0002830	positive regulation of type 2 immune response
GO:0006569	tryptophan catabolic process
GO:0006954	inflammatory response
GO:0007565	female pregnancy
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019805	quinolinate biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0032693	negative regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0033555	multicellular organismal response to stress
GO:0034276	kynurenic acid biosynthetic process
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0036269	swimming behavior
GO:0042098	T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0046006	regulation of activated T cell proliferation
GO:0070233	negative regulation of T cell apoptotic process
GO:0070234	positive regulation of T cell apoptotic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030485	smooth muscle contractile fiber
GO:0032421	stereocilium bundle

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6e42, PDBe:6e42, PDBj:6e42
PDBsum	6e42
PubMed	30387777
UniProt	P14902\|I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 (Gene Name=IDO1)

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