Structure of PDB 6dxx Chain D

Receptor sequence
>6dxxD (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
CTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFI
GYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLS
ESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLD
PLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQIL
SVVPVYNNFTIYTTVMSAGSPDKYMTRIRNP
3D structure
PDB6dxx Molecular mechanism of activation of the immunoregulatory amidase NAAA.
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.23: ceramidase.
3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TON D W201 L209 W76 L84
BS02 WTF D Y146 L152 L155 F174 I175 Y177 W181 E195 Y21 L27 L30 F49 I50 Y52 W56 E70 BindingDB: IC50=500nM
External links
PDB RCSB:6dxx, PDBe:6dxx, PDBj:6dxx
PDBsum6dxx
PubMed30301806
UniProtQ02083|NAAA_HUMAN N-acylethanolamine-hydrolyzing acid amidase (Gene Name=NAAA)

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