Structure of PDB 6dwo Chain D

Receptor sequence

>6dwoD (length=712) Species: 226185 (Enterococcus faecalis V583)

MNIQAIDTRHGTANQHSFSNGNCLPYTGVPFGMNFYAPQTTDQKGSWWFH
PEDRTFQGYRVTHQPSPWMGDFSHLLMTPVSGSLSELSLFHAQSSYRPEE
SLFSPVEINLTQLRYQITSQLIPSMYGGILTIDYQQKDNHLLLTLPGRYQ
VKQLDDHQVAVKVINYSGCEDPDFSFYFVLHFEQPLTKWFAPSSGEDGKI
LLSFGNIAQQVVHFSSSFISEKQAQLNLAREISLRSTEMLQQGIADWHNY
FDRLKVTHENPEHTKTFYHTLYRTFLFPQTFYELDENQQPIHYDTFSQTV
RPGVLYTNNGFWDTYKTVYPLFSLIAQEKYEEMLEGFLNSYNETGFLPKW
LSPDERGLMPGTLIDAVIADAAVKKIRPDLMPQFLEAMKKGATQQSEREN
YGRQGTLDYLKYGYVPSTYHESVNHTLDYAYSDFCISQVAKTLNDSETAT
FYRQQALNYQQLFNPETGFMQAKDTEGNFRPDFLDIRWGKDYAEGSAWQS
SFAVYQDFAGLIKLYGSELAFEKKLIQLCNQAPNFNVEGYGFEIHEMSEM
AAIDFGQLAISNQPSFHYPFLFSYIGKPEMAQPLLKQLMQTFDASPTGYP
GDEDNGSMSAWYIFNSLGFYPVTPGTGEYVIGMPLVQTAEVKLSNGKQLT
IQTSPNKVQQQFIHEIQLNQEKHTAPYFTHQELLNGGTLDYQLGIVPNPQ
NTAERPFSLSTE

3D structure

• PDB: 6dwo Enterococcus faecalis alpha 1-2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification.
• Chain: D
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 3.2.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	D	N562 Q563 D604	N562 Q563 D604
BS02	K	D	N20 T597 Y599 P600	N20 T597 Y599 P600

Gene Ontology

Molecular Function

• GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
• GO:0003824 catalytic activity
• GO:0030246 carbohydrate binding
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
• GO:0006516 glycoprotein catabolic process
• GO:0006517 protein deglycosylation

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:6dwo, PDBe:6dwo, PDBj:6dwo
• PDBsum: 6dwo
• PubMed: 31552675
• UniProt: Q832K9