Structure of PDB 6dwk Chain D

Receptor sequence

>6dwkD (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDC
HHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLH
RRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYT
KLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKR
EDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSF
YCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFV
QWCADRNFTKPQDGDVIAPLITPQKKEW

3D structure

PDB

6dwk The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	D	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS02	GTP	D	Y155 V156 V378 R451 K455	Y43 V44 V258 R331 K335
BS03	DTP	D	V156 F157 R372 H376 K377	V44 F45 R252 H256 K257
BS04	DTP	D	V117 N119	V5 N7
BS05	DTP	D	R333 R352 K354 N358 K523	R213 R232 K234 N238 K403
BS06	HFD	D	Q149 L150 R206 H215 K312 Y315 D319 R366 H370 Y374 Q375	Q37 L38 R94 H103 K192 Y195 D199 R246 H250 Y254 Q255
BS07	GLY	D	G324 Q326	G204 Q206
BS08	GLY	D	V487 L488 Y563	V367 L368 Y443

External links

PDB	RCSB:6dwk, PDBe:6dwk, PDBj:6dwk
PDBsum	6dwk
PubMed	30305425
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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