Structure of PDB 6dwe Chain D

Receptor sequence
>6dweD (length=399) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAYQKERVSQDFLDDL
DRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKINNVLGQ
ALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQAL
NVARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGP
HPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIGIFHAF
LDDPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQDEDGQT
IESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEG
IIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVETAAKWFGLL
3D structure
PDB6dwe Crystal structure of tryptophan synthase from M. tuberculosis - closed form with BRD6309 bound
ChainD
Resolution2.691 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K101 E123 S390
Catalytic site (residue number reindexed from 1) K93 E115 S382
Enzyme Commision number 4.2.1.20: tryptophan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P1T D H100 K101 T124 G125 A126 G127 Q128 H129 T204 G246 G248 S249 N250 G317 E364 S390 H92 K93 T116 G117 A118 G119 Q120 H121 T196 G238 G240 S241 N242 G309 E356 S382
BS02 HDJ D I184 F188 F202 P208 F211 H294 I176 F180 F194 P200 F203 H286
Gene Ontology
Molecular Function
GO:0004834 tryptophan synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process
GO:1901605 alpha-amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6dwe, PDBe:6dwe, PDBj:6dwe
PDBsum6dwe
PubMed
UniProtP9WFX9|TRPB_MYCTU Tryptophan synthase beta chain (Gene Name=trpB)

[Back to BioLiP]