Structure of PDB 6dvc Chain D

Receptor sequence
>6dvcD (length=1264) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIF
GPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVT
HIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLE
AEMAVERKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGE
REMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYF
TGAMGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVAAF
QQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNN
RLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSL
SDLLKGKQGRFRQNLLGKVDYSGRSVIVVGPQLKLHQCGLPKLMALELFK
PFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPT
LHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQA
EARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPAS
GDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPVEIEAELFGH
SGWQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAER
YPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERA
DKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIV
DSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINT
HGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAE
RAPDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALL
AAGITQVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSI
GEPGTQLTGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIV
PDDGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSAD
PHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTI
IDSGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLAT
DSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRY
RNIAVQPTEEARAA
3D structure
PDB6dvc Structural basis of ECF-sigma-factor-dependent transcription initiation.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D Q287 K409 R427 A868 Y872 Q1227 E1228 Q285 K407 R424 A865 Y869 Q1210 E1211
BS02 dna D P111 P122 K123 R291 K294 R1038 P109 P120 K121 R289 K292 R1021
BS03 rna D R500 D537 D539 R497 D534 D536
BS04 ZN D C891 C968 C975 C978 C888 C965 C972 C975
BS05 ZN D C60 C62 C75 C58 C60 C73
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dvc, PDBe:6dvc, PDBj:6dvc
PDBsum6dvc
PubMed30755604
UniProtP9WGY7|RPOC_MYCTU DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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