Structure of PDB 6du6 Chain D

Receptor sequence
>6du6D (length=505) Species: 7159 (Aedes aegypti) [Search protein sequence]
SVSHLEHMCSLDIDSQTAFVRLSGIICTIGPASVAPEMLEKMMATGMNIA
RLNFSHGSHEYHANTIKNIREAVDNYSKKQGKPFPLAIALDTKGPEIRTG
LIEGSGTGEVELKKGEQIQLTTDKDHLEKGSKDKIFVDYVNIVKVVKKGD
RVFVDDGLISLVVDSISGDTLTCTVENGGLLGSRKGVNLPGVPVDLPAVS
EKDKSDLQFGVEQGVDVIFASFIRNAAALKEIRTILGEKGKNIKIISKIE
NQQGMQNLDAIIAASDGIMVARGDLGIEIPAEKVFLAQKSMIARCNRAGK
PVICATQMLESMIKKPRPTRAEISDVANAIIDGADCVMLSGETAKGEYPL
ECVLTMAKTCKEAEAALWHRNLFNDLVNTTPTPLDTASSIAIAASEAAAK
SRAAAVIVITTSGRSAHLISKYRPRCPIIAVTRFAQTARQCHLYRGILPV
IYEQQALEDWLKDVDARVQYGMDFGKERGFLKPGNPVVVVTGWKFTNTIR
IVNVE
3D structure
PDB6du6 Distinctive regulatory properties of pyruvate kinase 1 from Aedes aegypti mosquitoes.
ChainD
Resolution3.513 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R71 R118 K268 T326
Catalytic site (residue number reindexed from 1) R51 R98 K248 T306
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP D I429 T430 T431 S432 S435 W480 R487 G512 F519 I409 T410 T411 S412 S415 W460 R467 G492 F495
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6du6, PDBe:6du6, PDBj:6du6
PDBsum6du6
PubMed30578824
UniProtQ16F38

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