Structure of PDB 6dhm Chain D

Receptor sequence

>6dhmD (length=495) Species: 9913 (Bos taurus) [Search protein sequence]

ADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRETEEQKRNRVRGILR
IIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVS
VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTM
ELAKKGFIGPGVDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTG
KPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFAVQ
GFGNVGLHSMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKLQHGT
ILGFPKAKIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANG
PTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFK
YERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVH
SGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFRVYNE

3D structure

PDB

6dhm A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLU	D	K90 G91 G92 M111 K114 K126 A166 R211 V378 S381	K90 G91 G92 M111 K114 K126 A166 R211 V378 S381
BS02	NDP	D	D168 M169 R211 Q250 F252 G253 N254 V255 E275 S276 A326 A348 N349 N374	D168 M169 R211 Q250 F252 G253 N254 V255 E275 S276 A326 A348 N349 N374
BS03	GTP	D	H209 S213 R217 H258 R261 Y262 R265 E292 H450	H209 S213 R217 H258 R261 Y262 R265 E292 H450
BS04	ZN	D	H209 H450	H209 H450

Gene Ontology

	Molecular Function
GO:0004352	glutamate dehydrogenase (NAD+) activity
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity
GO:0004354	glutamate dehydrogenase (NADP+) activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016491	oxidoreductase activity
GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding

	Biological Process
GO:0006520	amino acid metabolic process
GO:0006538	glutamate catabolic process
GO:0006541	glutamine metabolic process
GO:0072350	tricarboxylic acid metabolic process

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6dhm, PDBe:6dhm, PDBj:6dhm
PDBsum	6dhm
PubMed	21749647
UniProt	P00366\|DHE3_BOVIN Glutamate dehydrogenase 1, mitochondrial (Gene Name=GLUD1)

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