Structure of PDB 6dg8 Chain D

Receptor sequence
>6dg8D (length=391) Species: 10090 (Mus musculus) [Search protein sequence]
TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQV
LTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVG
KSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWL
HTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSY
AEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKIT
LLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRL
VHKQDLQRPVPDWLRHLVLDRIAWILAVRGLLQELSSIRHFLEKRDEMRE
VARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
3D structure
PDB6dg8 Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor.
ChainD
Resolution3.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRO D T154 W156 F199 I201 Y207 T147 W149 F192 I194 Y200 BindingDB: Ki=361nM,EC50=3400nM
BS02 SRO D W63 Y64 Y126 W56 Y57 Y119 BindingDB: Ki=361nM,EC50=3400nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0022850 serotonin-gated monoatomic cation channel activity
GO:0042802 identical protein binding
GO:0051378 serotonin binding
GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Biological Process
GO:0006811 monoatomic ion transport
GO:0007210 serotonin receptor signaling pathway
GO:0034220 monoatomic ion transmembrane transport
GO:0098662 inorganic cation transmembrane transport
GO:0099505 regulation of presynaptic membrane potential
GO:0140227 serotonin-gated cation-selective signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032154 cleavage furrow
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:1904602 serotonin-activated cation-selective channel complex

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Cellular Component
External links
PDB RCSB:6dg8, PDBe:6dg8, PDBj:6dg8
PDBsum6dg8
PubMed30401837
UniProtP23979|5HT3A_MOUSE 5-hydroxytryptamine receptor 3A (Gene Name=Htr3a)

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