Structure of PDB 6d6t Chain D

Receptor sequence
>6d6tD (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEY
TIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAH
NMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSY
AYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEY
VVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGV
TTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF
TKSQPARAAKIDRLSRIAFPLLFGIFNLVYWATYLNR
3D structure
PDB6d6t Structure of a human synaptic GABAAreceptor.
ChainD
Resolution3.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU D F65 R67 F55 R57 BindingDB: EC50=80000nM,Ki=21.37nM
BS02 FYP D H102 Y160 S205 Y210 H92 Y150 S195 Y200 PDBbind-CN: -logKd/Ki=8.21,Kd=6.1nM
BindingDB: Ki=0.80nM
BS03 Y01 D V227 W341 V217 W331
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6d6t, PDBe:6d6t, PDBj:6d6t
PDBsum6d6t
PubMed29950725
UniProtP14867|GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=GABRA1)

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