Structure of PDB 6cwy Chain D

Receptor sequence
>6cwyD (length=487) Species: 9606 (Homo sapiens) [Search protein sequence]
LSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTI
DGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALD
NRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQ
RTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAW
EPTEAEAISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPV
PLDWAEVQSQLDVKSYARLFSKSIETLRVHLIWDKDDPSAMDFVTSAANL
RMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKID
QCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTV
LTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGI
RNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVG
3D structure
PDB6cwy Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
ChainD
Resolution2.462 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D117 C173 T174 R176
Catalytic site (residue number reindexed from 1) D100 C156 T157 R159
Enzyme Commision number 2.3.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C158 C161 C441 C444 C141 C144 C380 C383
BS02 MG D I96 Y101 H124 I79 Y84 H107
BS03 FHJ D C30 K34 S79 V80 F83 C28 K32 S62 V63 F66
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0016740 transferase activity
GO:0019948 SUMO activating enzyme activity
GO:0032183 SUMO binding
GO:0044388 small protein activating enzyme binding
GO:0044390 ubiquitin-like protein conjugating enzyme binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0016925 protein sumoylation
GO:0033235 positive regulation of protein sumoylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031510 SUMO activating enzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cwy, PDBe:6cwy, PDBj:6cwy
PDBsum6cwy
PubMed30514846
UniProtQ9UBT2|SAE2_HUMAN SUMO-activating enzyme subunit 2 (Gene Name=UBA2)

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