Structure of PDB 6cgg Chain D

Receptor sequence
>6cggD (length=289) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
DNATNVKAMKYLIEHYFDNFKVDSIEIIGSGSVAYLVNNEYIFKTKFKGY
AKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIY
STMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRE
TIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNR
LTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKA
KEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRT
3D structure
PDB6cgg Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 84G D D374 N378 H379 Y408 E411 E415 E445 Y448 E451 D187 N191 H192 Y221 E224 E228 E258 Y261 E264
BS02 GNP D G211 S214 I224 K226 Y274 I277 F281 I392 D393 G31 S32 I42 K44 Y87 I90 F94 I205 D206
BS03 MG D H379 D393 H192 D206
External links
PDB RCSB:6cgg, PDBe:6cgg, PDBj:6cgg
PDBsum6cgg
PubMed29661878
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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