Structure of PDB 6cac Chain D

Receptor sequence
>6cacD (length=231) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
GHMETGDQRFGDLVFRQLAPNVWQHTSYLDFGAVAPSNGLIVRDGGRVLV
VDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIA
TYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPG
HTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGA
AFPKASMIVMSHSAPDSRAAITHTARMADKL
3D structure
PDB6cac The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
ChainD
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H121 H123 D125 H190 C209 K212 N221 H251
Catalytic site (residue number reindexed from 1) H82 H84 D86 H151 C170 K173 N182 H212
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H121 H123 H190 H82 H84 H151
BS02 CO D E153 D224 E114 D185
BS03 CA D D96 D131 D57 D92
External links
PDB RCSB:6cac, PDBe:6cac, PDBj:6cac
PDBsum6cac
PubMed30348667
UniProtC7C422|BLAN1_KLEPN Metallo-beta-lactamase type 2 (Gene Name=blaNDM-1)

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