Structure of PDB 6c7j Chain D

Receptor sequence
>6c7jD (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
YTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINN
YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL
EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHF
AQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQ
KMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFF
SQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKA
AELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLD
3D structure
PDB6c7j Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes.
ChainD
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EPV D H656 T768 L770 D808 L809 I826 M845 M847 F862 H75 T187 L189 D227 L228 I245 M264 M266 F281 MOAD: ic50=1.32nM
BS02 ZN D H660 H696 D697 D808 H79 H115 D116 D227
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6c7j, PDBe:6c7j, PDBj:6c7j
PDBsum6c7j
PubMed30070482
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

[Back to BioLiP]