Structure of PDB 6c71 Chain D

Receptor sequence

>6c71D (length=439) Species: 1042876 (Pseudomonas putida S16) [Search protein sequence]

FDYDVVVVGGGFAGATAARECGLQGYRTLLLEARSRLGGRTFTSRFAGQE
IEFGGAWVHWLQPHVWAEMQRYGLGVVEDPLTNLDKTLIMYNDGSVESIS
PDEFGKNIRIAFEKLCHDAWEVFPRPHEPMFTERARELDKSSVLDRIKTL
GLSRLQQAQINSYMALYAGETTDKFGLPGVLKLFACGGWNYDAFMDTETH
YRIQGGTIGLINAMLTDSGAEVRMSVPVTAVEQVNGGVKIKTDDDEIITA
GVVVMTVPLNTYKHIGFTPALSKGKQRFIKEGQLSKGAKLYVHVKQNLGR
VFAFADEQQPLNWVQTHDYSDELGTILSITIARKETIDVNDRDAVTREVQ
KMFPGVEVLGTAAYDWTADPFSLGAWAAYGVGQLSRLKDLQAAEGRILFA
GAETSNGWHANIDGAVESGLRAGREVKQLLSLEHHHHHH

3D structure

PDB

6c71 Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.

Chain

Resolution

2.649 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H110
Catalytic site (residue number reindexed from 1)	H59
Enzyme Commision number	1.4.2.2: nicotine dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NCT	D	L217 Y218 T250 W364 T381 W427 A461	L166 Y167 T199 W313 T330 W376 A410
BS02	FAD	D	V59 G60 G62 A64 E83 A84 R85 G90 R91 T92 G105 G106 A107 W108 P278 V279 V308 P309 W417 F422 W427 G452 A453 N462 I463 A466	V8 G9 G11 A13 E32 A33 R34 G39 R40 T41 G54 G55 A56 W57 P227 V228 V257 P258 W366 F371 W376 G401 A402 N411 I412 A415

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:6c71, PDBe:6c71, PDBj:6c71
PDBsum	6c71
PubMed	29812904
UniProt	F8G0P2\|NICA2_PSEP6 Nicotine dehydrogenase (Gene Name=nicA2)

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