Structure of PDB 6c4d Chain D

Receptor sequence
>6c4dD (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
MSLNVIKMKSSDFLESAGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALL
EEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTP
LSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLAS
FKMWSKLNNEGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEP
YENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPT
FPGIEEKFRPFYLSQL
3D structure
PDB6c4d Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
ChainD
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D127 K129 E131 N132 D145 T162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EJP D V31 I43 K45 M67 V76 M92 A155 D156 L157 F162 V20 I32 K34 M56 V65 M81 A144 D145 L146 F151 BindingDB: IC50=1.3nM,Ki=0.912011nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6c4d, PDBe:6c4d, PDBj:6c4d
PDBsum6c4d
PubMed29485864
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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