Structure of PDB 6bwi Chain D

Receptor sequence

>6bwiD (length=816) Species: 9606 (Homo sapiens)

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADELRL
AVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHLG
HFLTPMRLAQLYSAAPSNSLIRNLLDQASGFGESMYLLSDKATSWSDLLL
WALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKD
LAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADAR
AFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRCLR
RWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFW
AFTLLCEELRQGLASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPG
LYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF
LGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVA
LMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLV
NLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLR
LLLRQLKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLA
LKQLGHIREYEQRLKV

3D structure

• PDB: 6bwi Structure of full-length human TRPM4.
• Chain: D
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	D	W864 I920 S924 L934	W528 I584 S588 L598
BS02	Y01	D	P960 L963 F967	P624 L627 F631
BS03	Y01	D	I690 V694 F783 N913	I426 V430 F463 N577
BS04	Y01	D	I1026 L1034	I690 L698
BS05	Y01	D	S863 W864 C867 M900 V904	S527 W528 C531 M564 V568

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6bwi, PDBe:6bwi, PDBj:6bwi
• PDBsum: 6bwi
• PubMed: 29463718
• UniProt: Q8TD43|TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (Gene Name=TRPM4)