Structure of PDB 6btz Chain D

Receptor sequence
>6btzD (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
IGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTS
KRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFL
GGVTLPLKDFNLSKETVKWYQLTAAT
3D structure
PDB6btz Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha.
ChainD
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O4B D V1675 W1677 V117 W119
BS02 O4B D D1667 F1668 K1676 Y1678 D109 F110 K118 Y120
BS03 O4B D K1582 D1583 W1677 K24 D25 W119
External links
PDB RCSB:6btz, PDBe:6btz, PDBj:6btz
PDBsum6btz
PubMed30293811
UniProtO00443|P3C2A_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Gene Name=PIK3C2A)

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