Structure of PDB 6bjd Chain D

Receptor sequence
>6bjdD (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICEN
PRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIEN
YAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKA
YAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIER
GSLMGCSIDYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQ
VEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLE
ICNLT
3D structure
PDB6bjd Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
ChainD
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q123 C129 H334 N358 W360
Catalytic site (residue number reindexed from 1) Q65 C71 H222 N246 W248
Enzyme Commision number 3.4.22.54: calpain-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D I113 D114 G115 N117 D120 E199 I55 D56 G57 N59 D62 E141
BS02 CA D E364 D371 T392 D394 E396 E252 D259 T280 D282 E284
BS03 E64 D Q123 G127 C129 G222 N223 S265 H334 Q65 G69 C71 G164 N165 S207 H222
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bjd, PDBe:6bjd, PDBj:6bjd
PDBsum6bjd
PubMed29382717
UniProtP20807|CAN3_HUMAN Calpain-3 (Gene Name=CAPN3)

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