Structure of PDB 6b5v Chain D

Receptor sequence
>6b5vD (length=589) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAV
GETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQ
NLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEI
VRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDH
LQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLY
DLTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPY
FCVLASLYILYMICFTTCCIYRPLKLRAYVTHQDNIRLVGELVTVTGAVI
ILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMN
GEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMA
VVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYS
VDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV
ATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHH
3D structure
PDB6b5v Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
ChainD
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ECL D F425 F456 L460 F377 F408 L412
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005516 calmodulin binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0035809 regulation of urine volume
GO:0051289 protein homotetramerization
GO:0055074 calcium ion homeostasis
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098703 calcium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6b5v, PDBe:6b5v, PDBj:6b5v
PDBsum6b5v
PubMed29323279
UniProtQ9XSM3|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 (Gene Name=Trpv5)

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