Structure of PDB 6b0o Chain D

Receptor sequence

>6b0oD (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]

RPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQL
KRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQK
KFARSDELVRHHNMHQ

3D structure

PDB

6b0o Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.

Chain

Resolution

1.552 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	R362 R366 Q369 R372 H373 R376 R390 S393 R394 H397 H401 T404 R424 E427 R430	R42 R46 Q49 R52 H53 R56 R70 S73 R74 H77 H81 T84 R104 E107 R110	PDBbind-CN: Kd=45nM
BS02	dna	D	S367 K399 S425 R430	S47 K79 S105 R110	PDBbind-CN: Kd=45nM
BS03	ZN	D	C355 C360 H373 H377	C35 C40 H53 H57
BS04	ZN	D	C385 C388 H401 H405	C65 C68 H81 H85
BS05	ZN	D	C413 C418 H431 H435	C93 C98 H111 H115
BS06	ZN	D	C325 C330 H343 H347	C5 C10 H23 H27

External links

PDB	RCSB:6b0o, PDBe:6b0o, PDBj:6b0o
PDBsum	6b0o
PubMed	29294058
UniProt	P19544\|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)

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