Structure of PDB 6awj Chain D

Receptor sequence
>6awjD (length=261) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MKVGIDAGGTLIKIVQERTFKTELTKNIDQVVEWLNQQQIEKLCLTGGNA
GVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTGTSLH
YFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRNTIDL
KVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVGEVV
TTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVENG
AFSGAIGALYL
3D structure
PDB6awj Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N7G D T172 A173 E202 Y240 T168 A169 E198 Y236
BS02 N7G D F71 R113 G116 I117 F67 R109 G112 I113
BS03 ADP D G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 G224 S225 S226 G8 G9 T10 L11 K13 G94 T95 G117 Q121 Y133 G220 S221 S222
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6awj, PDBe:6awj, PDBj:6awj
PDBsum6awj
PubMed
UniProtQ2FWC7|COAW_STAA8 Type II pantothenate kinase (Gene Name=coaW)

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