Structure of PDB 6awh Chain D

Receptor sequence
>6awhD (length=264) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MKVGIDAGGTLIKIVQEQDQRTFKTELTKNIDQVVEWLNQQQIEKLCLTG
GNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTGT
SLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRNT
IDLKVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVG
EVVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYV
ENGAFSGAIGALYL
3D structure
PDB6awh Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
ChainD
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP D G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 G224 S225 S226 G8 G9 T10 L11 K13 G97 T98 G120 Q124 Y136 G223 S224 S225
BS02 N7G D L171 T172 A173 E202 Y240 L170 T171 A172 E201 Y239
BS03 N7G D F71 G100 R113 G116 I117 F70 G99 R112 G115 I116
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6awh, PDBe:6awh, PDBj:6awh
PDBsum6awh
PubMed
UniProtQ2FWC7|COAW_STAA8 Type II pantothenate kinase (Gene Name=coaW)

[Back to BioLiP]