Structure of PDB 6ajc Chain D

Receptor sequence
>6ajcD (length=413) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
SQKIKVAGTVVELDGDEMTRVIWKMIKEELIFPFLDVPIEYYDLGMENRD
KTDDQVTVDAAHAIKKHGVGVKCATITPDEARVREFNLKQMWKSPNGTIR
NILGGTVFREPIMCKNVPRLVTTWKHPIVIGRHAFGDQYRATDLVVNGPG
TFEIHFVPESGGAAQVQKVFDFKSGGVLMGMYNTDESIKDFAKSCFEYAL
SKKWPLYLSTKNTILKRYDGRFKDIFAEMYKASYEADYKKAGIWYEHRLI
DDMVAYAMKSEGGYVWACKNYDGDVQSDSVAQGFGSLGLMTSVLMSPDGR
TVEAEAAHGTVTRHYRQHQKGEETSTNPVASIFAWTRGLMHRGKLDQNEK
LVQFSMLLEKVVVSTIEAGFMTKDLAICIKGMNHVTRSDYLNTQEFIHKL
ADEMRKAYERSKI
3D structure
PDB6ajc Biochemical characterization of a novel Trypanosoma brucei glycosomal isocitrate dehydrogenase with dual coenzyme specificity (NADP+/NAD+)
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D D252 K259 D252 K259
BS02 NAP D A74 T75 I76 T77 R82 N96 L287 H308 G309 T310 V311 T312 R313 H314 T326 N327 A74 T75 I76 T77 R82 N96 L287 H308 G309 T310 V311 T312 R313 H314 T326 N327
BS03 CA D D274 D278 D274 D278
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006739 NADP metabolic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ajc, PDBe:6ajc, PDBj:6ajc
PDBsum6ajc
PubMed
UniProtQ4E4L7

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