Structure of PDB 6ahe Chain D

Receptor sequence

>6aheD (length=260) Species: 575584 (Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841) [Search protein sequence]

QGLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDE
FAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTL
DGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGS
ERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASG
IKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDA
GFNTVGMSQS

3D structure

PDB

6ahe Ternary complex formation of AFN-1252 with Acinetobacter baumannii FabI and NADH: Crystallographic and biochemical studies.

Chain

Resolution

2.29 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	D	G15 A17 S21 I22 P42 D66 V67 S93 I94 G95 L147 T148 K166 A192 I195 T197 L198 A199	G13 A15 S19 I20 P40 D64 V65 S91 I92 G93 L145 T146 K164 A190 I193 T195 L196 A197
BS02	0WE	D	F96 A97 L102 Y149 N158 Y159 A199 S201 I203 F206	F94 A95 L100 Y147 N156 Y157 A197 S199 I201 F204

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004318	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491	oxidoreductase activity

	Biological Process
GO:0006633	fatty acid biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6ahe, PDBe:6ahe, PDBj:6ahe
PDBsum	6ahe
PubMed	32227402
UniProt	D0CAD5

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