Structure of PDB 6a60 Chain D

Receptor sequence
>6a60D (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
EDMPVERILEAELAVDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQ
VILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD
RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVY
ASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI
DTFLMEMLEA
3D structure
PDB6a60 Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
ChainD
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D F277 V280 K284 L294 V298 R302 T449 F450 E453 E456 A457 F30 V33 K37 L47 V51 R55 T202 F203 E206 E209 A210
BS02 9CR D I268 A272 Q275 L309 F313 R316 A327 C432 I21 A25 Q28 L62 F66 R69 A80 C185 BindingDB: EC50=100nM,Ki=583nM,IC50=32nM,Kd=240nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6a60, PDBe:6a60, PDBj:6a60
PDBsum6a60
PubMed30275017
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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