Structure of PDB 5zyt Chain D

Receptor sequence
>5zytD (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
VPQNWFPIFNPERPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERWKQRM
ILELGEDGFKEYTSNVFLQGKRFHEALESILSPQENLLKSGYIESVQHIL
KDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPFIQ
STFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAEL
CSQYWTKWLLRLEEYTEKKK
3D structure
PDB5zyt Structural insights into DNA degradation by human mitochondrial nuclease MGME1
ChainD
Resolution2.702 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D L125 E150 T169 F173 L19 E44 T63 F67
BS02 dna D S132 V133 T134 Q145 L149 W152 F173 G176 H180 G235 L236 D238 T254 E256 K257 K259 S264 F266 Y275 S26 V27 T28 Q39 L43 W46 F67 G70 H74 G122 L123 D125 T141 E143 K144 K146 S151 F153 Y162
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008297 single-stranded DNA exodeoxyribonuclease activity
GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0043504 mitochondrial DNA repair
Cellular Component
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5zyt, PDBe:5zyt, PDBj:5zyt
PDBsum5zyt
PubMed30247721
UniProtQ9BQP7|MGME1_HUMAN Mitochondrial genome maintenance exonuclease 1 (Gene Name=MGME1)

[Back to BioLiP]