Structure of PDB 5zwk Chain D

Receptor sequence

>5zwkD (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]

DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYG
IAGVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVC
FDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYAL
YGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA
KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPA
NKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPV
ILGSPDDVLEFLKVYEKHS

3D structure

PDB

5zwk Location of FBPase catalytic metal binding site: a combined experimental and theoretical study

Chain

Resolution

2.104 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.3.11: fructose-bisphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FBP	D	E97 D121 G122 S123 N212 Y215 Y244 G246 M248 Y264 K274 R276	E81 D105 G106 S107 N196 Y199 Y228 G230 M232 Y248 K258 R260
BS02	AMP	D	V17 E20 G21 A24 T27 E29 L30 K112 Y113 M177	V9 E12 G13 A16 T19 E21 L22 K96 Y97 M161
BS03	MG	D	E97 D118 L120	E81 D102 L104
BS04	MG	D	D118 D121 E280	D102 D105 E264

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0046872	metal ion binding

	Biological Process
GO:0005975	carbohydrate metabolic process
GO:0006094	gluconeogenesis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5zwk, PDBe:5zwk, PDBj:5zwk
PDBsum	5zwk
PubMed
UniProt	Q2TU34

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