Structure of PDB 5zg0 Chain D

Receptor sequence
>5zg0D (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
GSNKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKL
KNKWWYDKGECG
3D structure
PDB5zg0 TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
ChainD
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9C3 D I502 P515 S518 K751 G752 I92 P105 S108 K218 G219
BS02 GLU D Y471 L500 T501 R506 G674 S675 T676 E726 Y61 L90 T91 R96 G141 S142 T143 E193
BS03 ZN D H433 E440 H23 E30
BS04 ZN D E452 H456 E42 H46
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5zg0, PDBe:5zg0, PDBj:5zg0
PDBsum5zg0
PubMed30209408
UniProtP42262|GRIA2_HUMAN Glutamate receptor 2 (Gene Name=GRIA2)

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