Structure of PDB 5yhw Chain D

Receptor sequence

>5yhwD (length=387) Species: 9823 (Sus scrofa) [Search protein sequence]

TVKVINDPIHGHIELHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVRELSEKQPELQISERDMLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPDVKWTHEQGSVNMFEHLVNSNGLIDVMEHYGLIPEE
DIWFIKEQITWPYKGRPKEKSFLYEIVANKRNGIDVDKWDYFARDCHHLG
IQNNFDYKRFIKFARVCEVDNKKHICTREKEVGNLYDMFHTRNCLHRRAY
QHKVGNIIDTMITDAFLKADPYIEITGKKYRISTAIDDMEAFTKLTDNIF
LEILYSTDPKLDAARAILKKIECRNLYKFVIVDVINMDYGMEDKNPIDNV
RFYCKSDPNKAIIITKNQVSQLLPERFAEQLIRVYCK

3D structure

PDB

5yhw Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	D	V156 F157 I325 R372 H376 K377	V43 F44 I201 R248 H252 K253
BS02	DGT	D	V117 N119 H125	V4 N6 H12
BS03	DGT	D	R333 R352 K354 K524	R209 R228 K230 K355
BS04	DGT	D	Q149 L150 R164 R206 H210 H215 K312 Y315 R366 Y374 Q375	Q36 L37 R51 R93 H97 H102 K188 Y191 R242 Y250 Q251
BS05	MG	D	R206 D309	R93 D185
BS06	DGT	D	V156 V378 R451	V43 V254 R324

External links

PDB	RCSB:5yhw, PDBe:5yhw, PDBj:5yhw
PDBsum	5yhw
PubMed	31152619
UniProt	I3LG77

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