Structure of PDB 5yhv Chain D

Receptor sequence
>5yhvD (length=364) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DRVALRAGVPPFMDVWLAAAERQGDLVNLSAGQPSAGAPEPVRAAAAAAL
HLNQLGYSVALGIPELRDAIAADYQRRHGITVEPDAVVITTGSSGGFLLA
FLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQML
AEIDPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGL
VYQGAPQTSCAWQTSRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDC
LTGNFTICPPVLSQIAAVSAFTPEATAEADGNLASYAINRSLLLDGLRRI
DRLAPTDAFYVYDVSDFTSLAFCSKLLADTGVAIAPGIDFDTARGGFVRI
SFAGPSGDIEEALR
3D structure
PDB5yhv Crystal structure of an aminotransferase from Mycobacterium tuberculosis
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.66: valine--pyruvate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP D Y64 I265 Y57 I257
BS02 PLP D S100 S101 Y125 N174 D202 Y205 S231 S233 K234 R242 S93 S94 Y118 N166 D194 Y197 S223 S225 K226 R234
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008483 transaminase activity
GO:0009042 valine-pyruvate transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0009058 biosynthetic process
Cellular Component
GO:0009274 peptidoglycan-based cell wall

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Cellular Component
External links
PDB RCSB:5yhv, PDBe:5yhv, PDBj:5yhv
PDBsum5yhv
PubMed
UniProtP96847|AVTA_MYCTU Valine--pyruvate aminotransferase (Gene Name=aspB)

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