Structure of PDB 5y58 Chain D

Receptor sequence
>5y58D (length=560) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTDWISCYLA
NCPVSENSQEIPNVFQIQSFLAPVTTTATIGFIKRLKQYCDQHSMIQCLL
VVSLDIKQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRIILI
DCGSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGELRLGA
DILSTQTSNPSGSMQDENCLCIKVEAFPATKAVSGLNRKTAVEVEDSQKK
ERYVGVKSIIEYEIHNEGGSSYIPVTISKDSVTKAYRYGADYVVLPSVLV
DQTVYESFPGLDLRGFLNREALPRYFLTSESSFITADTRLGCQSDLMAFS
ALVDVMLENRKIAVARYVSKKDSEVNMCALCPVLIEHSNINSEKKFVKSL
TLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFVDSM
DTDELPEIPLGNYYQPIGEVTTDTTLPLPSLENKKDPLRIPTVFVYRQQQ
VLLEWIHQLMINDSREFEIPELPDSLKNKISPYTHKKFDSTKLVEVLGIK
KVKRGEQHSR
3D structure
PDB5y58 Structural Insights into Yeast Telomerase Recruitment to Telomeres
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D K39 R41 K42 T43 S204 K251 L256 N257 R258 S278 R318 Y323 V531 Q535 K38 R40 K41 T42 S184 K231 L236 N237 R238 S258 R287 Y292 V495 Q499 PDBbind-CN: Kd=75nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042162 telomeric DNA binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0007535 donor selection
GO:0031509 subtelomeric heterochromatin formation
GO:0034502 protein localization to chromosome
GO:0097695 establishment of protein-containing complex localization to telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y58, PDBe:5y58, PDBj:5y58
PDBsum5y58
PubMed29290466
UniProtQ04437|KU80_YEAST ATP-dependent DNA helicase II subunit 2 (Gene Name=YKU80)

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