Structure of PDB 5xwm Chain D

Receptor sequence
>5xwmD (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
SEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEE
FPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRS
VKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVF
ERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMT
NFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEI
FQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRH
MYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQVASS
PPESSFYRYTLLRDRDEL
3D structure
PDB5xwm Zinc regulates ERp44-dependent protein quality control in the early secretory pathway.
ChainD
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H277 H281 H278 H282
BS02 ZN D C29 Y78 C30 Y79
BS03 ZN D H299 H328 H332 H300 H329 H333
Gene Ontology
Molecular Function
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0006986 response to unfolded protein
GO:0009100 glycoprotein metabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0009986 cell surface
GO:0035580 specific granule lumen
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xwm, PDBe:5xwm, PDBj:5xwm
PDBsum5xwm
PubMed30723194
UniProtQ9BS26|ERP44_HUMAN Endoplasmic reticulum resident protein 44 (Gene Name=ERP44)

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