Structure of PDB 5xkh Chain D

Receptor sequence
>5xkhD (length=421) Species: 9823 (Sus scrofa) [Search protein sequence]
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLLTVPELTQQMFDSKNMMAACDPRHGRY
LTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTE
AESNMNDLVSEYQQYQDATAD
3D structure
PDB5xkh Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
ChainD
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 89C D A248 K252 L253 N256 A314 I316 N348 K350 A248 K252 L253 N256 A304 I306 N338 K340
BS02 GTP D G10 Q11 C12 Q15 A97 G98 N99 S138 G141 G142 T143 G144 E181 N204 Y222 N226 G10 Q11 C12 Q15 A97 G98 N99 S138 G141 G142 T143 G144 E181 N204 Y222 N226
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xkh, PDBe:5xkh, PDBj:5xkh
PDBsum5xkh
PubMed
UniProtP02554|TBB_PIG Tubulin beta chain

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