Structure of PDB 5xi5 Chain D

Receptor sequence

>5xi5D (length=421) Species: 41807 (Sus barbatus) [Search protein sequence]

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLLTVPELTQQMFDSKNMMAACDPRHGRY
LTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTE
AESNMNDLVSEYQQYQDATAD

3D structure

PDB

5xi5 Synthesis, biological evaluation and X-ray structure of anti-microtubule agents

Chain

Resolution

2.81 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GTP	D	G10 Q11 C12 A97 N99 S138 G141 G142 T143 G144 S176 E181 N204 Y222 N226	G10 Q11 C12 A97 N99 S138 G141 G142 T143 G144 S176 E181 N204 Y222 N226
BS02	PN6	D	N165 E198 Y200 V236 T237 C239 L240 L253 M257 A314 A352 I368	N165 E198 Y200 V236 T237 C239 L240 L253 M257 A304 A342 I358

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005525	GTP binding
GO:0046872	metal ion binding

	Biological Process
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0007017	microtubule-based process

	Cellular Component
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5xi5, PDBe:5xi5, PDBj:5xi5
PDBsum	5xi5
PubMed
UniProt	A0A0R4I995

[Back to BioLiP]