Structure of PDB 5w9c Chain D

Receptor sequence
>5w9cD (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSEYDPTRPFSMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYT
LKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKNVVPSYDLLLEML
3D structure
PDB5w9c Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
ChainD
Resolution1.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT D T347 A350 D351 E353 W383 M421 G521 L525 V533 T37 A40 D41 E43 W73 M111 G206 L210 V216 BindingDB: IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
External links
PDB RCSB:5w9c, PDBe:5w9c, PDBj:5w9c
PDBsum5w9c
PubMed29739819
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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