Structure of PDB 5w7c Chain D

Receptor sequence
>5w7cD (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
SDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDC
NDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRG
IILLGDAAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATG
FLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSR
NKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSH
LPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQV
SPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFH
EIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILG
KENPFNPQIKQVFGDQGGH
3D structure
PDB5w7c Crystal structure of the mammalian lipopolysaccharide detoxifier.
ChainD
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.77: acyloxyacyl hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D D184 D186 D188 Y190 D205 D208 D28 D30 D32 Y34 D49 D52
BS02 CA D D186 D188 D205 N207 D210 V213 D30 D32 D49 N51 D54 V57
BS03 CA D D223 D227 N229 N231 I233 E245 D67 D71 N73 N75 I77 E89
Gene Ontology
Molecular Function
GO:0016788 hydrolase activity, acting on ester bonds
GO:0050528 acyloxyacyl hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5w7c, PDBe:5w7c, PDBj:5w7c
PDBsum5w7c
PubMed29343645
UniProtP28039|AOAH_HUMAN Acyloxyacyl hydrolase (Gene Name=AOAH)

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