Structure of PDB 5vy9 Chain D

Receptor sequence

>5vy9D (length=721) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

QFTERALTILTLAQKLASDHQHPQLQPIHILAAFIETPEDGSVPYLQNLI
EKGRYDYDLFKKVVNRNLVRIPQQQPAPAEITPSYALGKVLQDAAKIQKQ
QKDSFIAQDHILFALFNDSSIQQIFKEAQVDIEAIKQQALELRGYLSKYA
IDMTEQARQGKLDPVIGREEEIRSTIRVLARRIKSNPCLIGEPGIGKTAI
IEGVAQRIIDDDVPTILQGAKLFSLDLAALTAGAKYKGDFEERFKGVLKE
IEESKTLIVLFIDEIHMLMGNGKDDAANILKPALSRGQLKVIGATTNNEY
RSIVEKDGAFERRFQKIEVAEPSVRQTVAILRGLQPKYEIHHGVRILDSA
LVTAAQLAKRYLPYRRLPDSALDLVDISCAGVAVARDSQNVVDSDTISET
AARLTGIPVKKLSESENEKLIHMERDLSSEVVGQMDAIKAVSNAVRLSRS
GLANPRQPASFLFLGLSGSGKTELAKKVAGFLFNDEDMMIRVDCSELSEK
YAVSKLLGTTAGYVGYDEGGFLTNQLQYKPYSVLLFDEVEKAHPDVLTVM
LQMLDDGRITSGQGKTIDCSNCIVIMTSNLGAEFINSQQGSKIQESTKNL
VMGAVRQHFRPEFLNRISSIVIFNKLSRKAIHKIVDIRLKEIEERFEQND
KHYKLNLTQEAKDFLAKYGYSDDMGARPLNRLIQNEILNKLALRILKNEI
KDKETVNVVLEECLEVLPNHE

3D structure

PDB

5vy9 Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Chain

Resolution

6.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	D	K256 Y257 K258 K649 Y662 V663	K235 Y236 K237 K500 Y513 V514
BS02	AGS	D	D184 V186 I187 P214 G215 I216 G217 K218 T219 A220	D163 V165 I166 P193 G194 I195 G196 K197 T198 A199
BS03	AGS	D	V580 V581 Q583 G617 S618 G619 K620 T621 E622 T726 L775 I783 R787 N829	V431 V432 Q434 G468 S469 G470 K471 T472 E473 T577 L626 I634 R638 N680

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0043531	ADP binding
GO:0051082	unfolded protein binding
GO:0051087	protein-folding chaperone binding

	Biological Process
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane
GO:0034605	cellular response to heat
GO:0034975	protein folding in endoplasmic reticulum
GO:0035617	stress granule disassembly
GO:0042026	protein refolding
GO:0043335	protein unfolding
GO:0051085	chaperone cofactor-dependent protein refolding
GO:0070370	cellular heat acclimation
GO:0070414	trehalose metabolism in response to heat stress

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034399	nuclear periphery
GO:0072380	TRC complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5vy9, PDBe:5vy9, PDBj:5vy9
PDBsum	5vy9
PubMed	28619716
UniProt	P31539\|HS104_YEAST Heat shock protein 104 (Gene Name=HSP104)

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