Structure of PDB 5vvc Chain D

Receptor sequence

>5vvcD (length=405) Species: 9606 (Homo sapiens)

KFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLAPEQLLS
QARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAK
QAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLR
SAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCI
QHGWTPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAA
LGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNI
LEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATA
SFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRY
QPDPW

3D structure

• PDB: 5vvc Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
• Chain: D
• Resolution: 2.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C184 R187 W356 E361
• Catalytic site (residue number reindexed from 1): C109 R112 W281 E286
• Enzyme Commision number: 1.14.13.39: nitric-oxide synthase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	D	C94 C99	C28 C33
BS02	HEM	D	W178 A181 R183 C184 V185 S226 M339 F353 S354 G355 W356 E361 F473 Y475	W103 A106 R108 C109 V110 S151 M264 F278 S279 G280 W281 E286 F398 Y400
BS03	H4B	D	S102 R365 A446 W447	S36 R290 A371 W372
BS04	9OJ	D	F105 V336 F353 W356 E361 W447	F39 V261 F278 W281 E286 W372	BindingDB: Ki=5760nM

Gene Ontology

Molecular Function

• GO:0004517 nitric-oxide synthase activity

Biological Process

• GO:0006809 nitric oxide biosynthetic process

External links

• PDB: RCSB:5vvc, PDBe:5vvc, PDBj:5vvc
• PDBsum: 5vvc
• PubMed: 28776992
• UniProt: P29474|NOS3_HUMAN Nitric oxide synthase 3 (Gene Name=NOS3)